Our Story: Why Methylation Matters at TRUMARK

TRUMARK is the methylation brand—built for people who want methylated vitamins and supplements that truly work. What started as a personal quest to optimize my health and understand my neurodivergence led to a science-backed line of methylated vitamins designed for MTHFR support, energy, focus, detoxification, and resilience.

My Discovery: ASD, Health Optimization, and a Missing Link

I’ve always been intensely focused and highly sensitive to stress, sound, and sensory input. On my journey to optimize how my body works, I learned I’m on the autism spectrum (ASD). That insight pushed me to investigate my health at a biochemical level. Through lab testing, research, and years of trial and error, I discovered a pivotal factor that explained my energy fluctuations, mood variability, and stress sensitivity: methylation.

What Is Methylation and Why It Matters

Methylation is a core biochemical process that helps your body activate and regulate neurotransmitters, detox pathways, hormones, and even gene expression. When methylation runs well, people often report better energy, focus, mood, sleep, and stress response. For many—especially those with MTHFR variants or high cognitive or sensory demands—methylation can be sluggish.

Active, “Ready-to-Use” Nutrients

  • 5-MTHF (methylfolate) – the active form of folate used in methylation cycles.
  • Methylcobalamin (B12) – bioactive B12 supporting energy and neurological health.
  • Pyridoxal-5-Phosphate (P5P, active B6) – coenzyme form essential for neurotransmitter synthesis.
  • Riboflavin-5-Phosphate (R5P, active B2) – supports homocysteine and methylation enzymes.
  • Choline, Betaine (TMG) – alternate methyl donors that support the broader methylation network.

The Problem with Non-Methylated Vitamins

Many mainstream formulas rely on cheaper, less effective forms like synthetic folic acid or cyanocobalamin. For people who don’t convert these efficiently, that can mean suboptimal results—and in some cases, congestion of the very pathways you’re trying to support. I kept seeing products that were close, but not complete: one or two methylated ingredients, but not full-spectrum methylation support. Labels weren’t always transparent, and dosages often didn’t match the research.

The Gap I Found: No True “Methylation Brand”

There wasn’t a single company focused solely on methylated nutrition—with rigorous transparency, clinical dosing, and formulations that respect how the body actually uses nutrients. I needed options that were fully methylated, clinically rational, and clean.

The Birth of TRUMARK — The Methylation Brand

I created TRUMARK to solve that problem. Our mission is simple: provide methylated vitamins and supplements that your body can absorb and use immediately—no unnecessary conversions, no compromises. Methylation Matters is more than a tagline; it’s our formulation philosophy.

Who TRUMARK Is For

  • Anyone seeking optimal energy, focus, mood, and stress resilience.
  • People with MTHFR or related methylation challenges who need active forms.
  • Neurodivergent individuals (including ASD) who want clean, predictable, bioavailable nutrition.
  • Health optimizers who expect clinical transparency and research-informed dosing.

Why TRUMARK Works

Full-Spectrum Methylation Support

We use active (coenzyme) B-vitamins—5-MTHF, methylcobalamin, P5P, R5P—plus choline and betaine (TMG) to support parallel methylation pathways. This creates redundancy and flexibility your biochemistry can rely on.

Bioavailability and Tolerability

Active forms are typically more bioavailable and better tolerated, helping reduce the guesswork and variability that can come with conversion-dependent nutrients.

Formulation Integrity

  • No synthetic folic acid or cyanocobalamin in core methylation products.
  • Clinically rational dosing with clear label transparency.
  • Clean excipients, mindful of sensitivities common in neurodivergent communities.

Our Quality Standards

  • Science-led formulations aligned with methylation pathways and homocysteine balance.
  • Third-party testing for identity, purity, potency, and contaminants.
  • GMP manufacturing and consistent batch-to-batch quality.
  • Transparent labels—every active form listed clearly.

The Invitation

TRUMARK isn’t just for people with ASD—it’s for anyone who wants to feel and perform their best with nutrients in their most absorbable, bioactive forms. When your methylation works, you work better.

FAQs

Is TRUMARK only for people with ASD?

No. TRUMARK is for anyone seeking the most bioavailable, active forms of vitamins to support methylation, energy, mood, and detox pathways.

Why are methylated vitamins different?

Methylated and coenzyme forms (like 5-MTHF, methylcobalamin, P5P) are “ready to use,” which can help if your body doesn’t efficiently convert standard forms.

Do I need genetic testing for MTHFR to benefit?

Not necessarily. Many people prefer active forms regardless of genotype because they’re efficient and predictable.